时间：2018年6月13日上午10：30

地点：大学城理六栋220会议室

报告主题：基于“Smartdisk”方法的护理点生物检测

报告人： 何浩培   教授  香港中文老员工物医学工程学系

概要：

芯片实验室（LoC）正成为现代医疗保健和医疗的主流平台。特别是个性化医疗，病人需要在进行任何定制治疗之前通过一系列筛查测试，这进一步增加了对快速，高效和低成本LoC生物测定装置的需求。我们报告一种基于“SmartDisk”的便携式无线LoC系统，能够在护理点级进行样本到答案的DNA筛选。通过旋转样品盘产生的离心力已被方便地用于以高度平行和可控制的方式致动多个流体样品和试剂。我们开发了一种无线电源耦合方案，用于驱动光盘平台中的有源器件。使用无线通信端口实现实时数据传输。这种主动式智能磁盘设备能够执行一系列样品处理步骤，包括微室之间样品和试剂的转移，细胞裂解，DNA扩增的温度循环以及通过监测荧光进行检测，从而实现样品至回答生物测定。作为示范性实验，我们报告从血液样本成功筛选药物过敏遗传标记并检测痰中的结核病等。

Title:  Point-of-care Biodetection based on a “Smartdisk” Approach

Abstract：

Lab-on-a-chip (LoC) is increasing becoming a mainstream platform in modern healthcare and medical industries. In particular, the so-called personalised medicine, which requires the patient to go through a series of screening tests before administering any customised therapy, further increases the demand for fast, efficient, and low-cost LoC bioassay devices.  In this presentation, we report a portable wireless LoC system, based on the “SmartDisk” approach, capable of conducting sample-to-answer DNA screening at point-of-care level. Centrifugal forces generated by spinning a sample disc have been conveniently used for the actuation of multiple fluidic samples and reagents in a highly parallel and controllable manner. We have developed a wireless power coupling scheme for driving the active devices in the disc platform. Real-time data transfer is achieved with the use of a wireless communication port. This active smartdisk device is capable of performing a series of sample processing steps, including transfer of samples and reagents between microchambers, cell lysis, temperature cycling for DNA amplification and detection through monitoring of fluorescence, for achieving sample-to-answer bioassays. As demonstration experiments, we report successful screening of drug allergy genetic markers from blood samples and detection of tuberculosis (TB) from sputum

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附：何浩培简历

香港中文老员工物醫學工程學系教授, SPIE (国际光学工程学会) 院士，HKIE (香港工程学会) 院士，惠普高级流程工程师 (1994-1996) ，香港城市大学物理与材料科学系助理教授 (1996-2002) ，香港中文大学工程学院副经理 (2007-9) ，香港光学工程学会主席(2010-12),副主席 (2013- ) ，研究领域: 表面等离子体共振生物传感器，芯片实验室和生物光子学，纳米复合半导体材料，发表文章~450篇，中国专利33篇，美国专利6篇。